Reaktion #526485

Reaktionsgleichung

n-Octyl bromide

4-(4-hydroxyphenyl)benzoic acid

sodium hydroxide

→

4'-n-octyloxy 1,1'-biphenyl

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   Sonstigepartitioned between ethyl acetate and water
3. 3
   WaschenThe organic phase is washed with water and brine
4. 4
   Sonstigethe solvent then removed

Vorschrift

n-Octyl bromide (0.102 mol) is added to a solution of 4-(4-hydroxyphenyl)benzoic acid (0.102 mol) and 2.5N sodium hydroxide (0.102 mol) and the mixture stirred at 70° C. for a period of 18 hours. The reaction mixture is allowed to cool and then acidified to pH 3 and partitioned between ethyl acetate and water. The organic phase is washed with water and brine and the solvent then removed to obtain the 4'-n-octyloxy 1,1'-biphenyl!-4-ylcarboxylic acid, C21H23O3, M.W. 326.4.

Quelle