Reaktion #52589

Reaktionsgleichung

5-chlorosulfonyl-2-oxindole

methylamine

→

5-methylaminosulfonyl-2-oxindole

Ausbeute 88.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeformed
2. 2
   FiltrationThe precipitate was collected by vacuum filtration
3. 3
   Waschenwashed twice with 5 mL of water
4. 4
   Sonstigedried under vacuum at 40° C. overnight

Vorschrift

A suspension of 3.38 g of 5-chlorosulfonyl-2-oxindole in 10 mL 2M methylamine in tetrahydrofuran was stirred at room temperature for 4 hours during which time a white solid formed. The precipitate was collected by vacuum filtration, washed twice with 5 mL of water and dried under vacuum at 40° C. overnight to give 3.0 g (88% yield) of 5-methylaminosulfonyl-2-oxindole.

Quelle