Reaktion #52588

ord-2520af5761ac4f8b8d7b07549287ce02

Reaktionsgleichung

O=C1Cc2cc(S(=O)(=O)Cl)ccc2N1
5-Chlorosulfonyl-2-oxindole
[NH4+].[OH-]
ammonium hydroxide
→
NS(=O)(=O)c1ccc2c(c1)CC(=O)N2
title compound
Ausbeute 20.0%
NS(=O)(=O)c1ccc2c(c1)CC(=O)N2
5-Aminosulfonyl-2-oxindole
Ausbeute 20.0%

Edukte

O=C1Cc2cc(S(=O)(=O)Cl)ccc2N1
5-Chlorosulfonyl-2-oxindole
[NH4+].[OH-]
ammonium hydroxide

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    EinengenThe mixture was concentrated
  2. 2
    Filtrationthe solid collected by vacuum filtration

Vorschrift

5-Chlorosulfonyl-2-oxindole (2.1 g) was added to 10 mL of ammonium hydroxide in 10 mL of ethanol and stirred at room temperature overnight. The mixture was concentrated and the solid collected by vacuum filtration to give 0.4 g (20% yield) of the title compound as an off-white solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06855730B2uspto-grants-2005_02