Reaktion #52567

Reaktionsgleichung

4-nitrophenol

HCl

formaldehyde dimethylacetal

→

2-chloromethyl-4-nitrophenol

Ausbeute 76.0%

Lösungsmittel

H2SO4

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 5-necked flask equipped with mechanical overhead stirrer, gas inlet tube
2. 2
   Temperaturreflux condenser
3. 3
   SonstigeGaseous HCl was bubbled through the mixture for 4 hours
4. 4
   SonstigeDuring this time a thick white precipitate formed
5. 5
   TemperaturThe suspension was cooled to 0° C.
6. 6
   Sonstigethe precipitate was isolated by vacuum filtration
7. 7
   Sonstigethe yellow powder was dried over night under vacuum

Vorschrift

A 5-necked flask equipped with mechanical overhead stirrer, gas inlet tube, reflux condenser and a thermometer was charged with 4-nitrophenol (100 g, 0.72 mol). Concentrated HCl 932%, 1.3 L), conc. H2SO4 (98%, 10 mL) and formaldehyde dimethylacetal (152.4 g, 2 moles) were added and the mixture was heated to 70° C. Gaseous HCl was bubbled through the mixture for 4 hours. During this time a thick white precipitate formed. The suspension was cooled to 0° C., the precipitate was isolated by vacuum filtration and the yellow powder was dried over night under vacuum to give 108.76 g of slightly impure 2-chloromethyl-4-nitrophenol (about 76% yield).

Quelle