Reaktion #5249

Reaktionsgleichung

Compound ( H )

1,3-dihydroxy-1-(4-methylthio-phenyl)-2-ethoxycarbonylamino-propane

→

( J )

5-(4-methylthio-phenyl)-4-hydroxymethyl-oxazolidin-2-one

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction mixture has been refluxed for 3 hours
2. 2
   SonstigeAfterwards, almost all of the solvent has been evaporated
3. 3
   workup.ADDITIONwater and ice have been added to the residue
4. 4
   Filtrationthe precipitate has been collected by filtration

Vorschrift

Compound (H) (5 g; 17.5 mmols) has been dissolved in warm toluene (25 ml). To this solution, an equimolar amount of potassium tert. butylate has been added and the reaction mixture has been refluxed for 3 hours. Afterwards, almost all of the solvent has been evaporated; water and ice have been added to the residue and the precipitate has been collected by filtration. The thus obtained crude (J) has been recrystallized from ethanol (3.7 g; yield, 88%); m.p. 130°-131° C.

Quelle