Reaktion #52436

Reaktionsgleichung

[4-(1-benzyloxycyclopropyl)-3-methyl-phenylethynyl]-trimethylsilane

ethyl 4-[4-(1-benzyloxycyclopropyl)-phenylethynyl]-benzoate

Intermediate 75

ethyl 4-[4-(1-benzyloxycyclopropyl)-phenylethynyl]-benzoate

potassium carbonate

→

4-Ethynyl-1-(1-benzyloxycyclopropyl)-2-methyl-benzene

Lösungsmittel

methanol

Reaktionsbedingungen

Vorschrift

Using General Procedure E; [4-(1-benzyloxycyclopropyl)-3-methyl-phenylethynyl]-trimethylsilane (Intermediate 75, 300.0 mg, 0.95 mmols) in methanol (6 mL) was treated with potassium carbonate (120.0 mg, 0.87 mmol) and stirred overnight at ambient temperature. The crude alkyne (185 mg, 79%) was used directly in the next reaction.

Quelle