Reaktion #524235

Reaktionsgleichung

magnesium

methyl iodide

1-(o-fluorobenzyl)-2-(dimethylaminoacetyl)pyrrole

methylmagnesium iodide

→

1-(dimethylamino)2-[1-(o-fluorobenzyl)-2-pyrryl]-2-hydroxypropane

Lösungsmittel

ether

ether

Reaktionsbedingungen

Vorschrift

A solution of 16.0 g of 1-(o-fluorobenzyl)-2-(dimethylaminoacetyl)pyrrole, free base of Example 3a, in 60 ml of ether is treated with a solution of methylmagnesium iodide, prepared from 2.7 g of magnesium turnings and 15.3 g of methyl iodide, in 40 ml of ether according to the procedure described in Example 9a to produce a crude yellow oil of 1-(dimethylamino)2-[1-(o-fluorobenzyl)-2-pyrryl]-2-hydroxypropane. Distillation at 130°-138° C./0.1 mm affords the product as a faintly yellow oil.

Quelle