Reaktion #52407

Reaktionsgleichung

triethyl amine

Intermediate 51

6-bromo-1-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro quinoline

(trimethylsilyl)acetylene

6-bromo-1-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro quinoline

→

title compound

1-Cyclopropyl-6-trimethylsilanylethynyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Vorschrift

Following general procedure D and using 6-bromo-1-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro quinoline (Intermediate 51, 0.8 g, 2.86 mmol), (trimethylsilyl)acetylene (5 mL, 35 mmol), triethyl amine (10 mL), anhydrous tetrahydrofuran, copper(I)iodide (0.080 g, 0.42 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.240 g, 0.34 mmol), the title compound was obtained as an oil (0.67 g, 79%).

Quelle