Reaktion #52400

Reaktionsgleichung

8-ethyl-6-ethynyl-2,2,4,4-tetramethylchroman

triethyl amine

methyl-4-iodo phenyl acetate

4-iodo phenyl acetic acid methyl ester

Reagent B

4-iodo phenyl acetic acid methyl ester

Intermediate 48

8-ethyl-6-ethynyl-2,2,4,4-tetramethylchroman

→

title compound

[4-(8-Ethyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)phenyl] acetic acid methyl ester

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Vorschrift

Following general procedure F and using 8-ethyl-6-ethynyl-2,2,4,4-tetramethylchroman (Intermediate 48, 0.033 g, 0.136 mmol), methyl-4-iodo phenyl acetate (Reagent B, 0.034 g, 0.12 mmol), triethyl amine (2 mL), tetrahydrofuran (2 mL), copper(I)iodide (0.025 g, 0.13 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.075 g, 0.11 mmol) the title compound was obtained (0.035 g, 73%).

Quelle