Reaktion #523986

Reaktionsgleichung

Sodium

2-hydroxypyrazolo[1,5-a]pyridine

dimethyl sulfate

→

oily product

Ausbeute 50.7%

2-methoxypyrazolo[1,5-a]pyridine

Ausbeute 50.7%

Lösungsmittel

methyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 8 hr
2. 2
   EinengenThe reaction mixture was concentrated
3. 3
   Sonstigeto remove methyl alcohol, and water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   ExtraktionThe solution was extracted with n-hexane
6. 6
   Trocknenthe n-hexane solution was dried over sodium sulfate
7. 7
   EinengenThe dried n-hexane solution was concentrated
8. 8
   workup.DISTILLATIONthe residue was distilled

Vorschrift

Sodium (92 mg) was dissolved in 5 ml of absolute methyl alcohol with moderate cooling. To this solution 2-hydroxypyrazolo[1,5-a]pyridine (500 mg) was added and then dimethyl sulfate (500 mg) was added. The mixture was stirred for 30 min. at room temperature and refluxed for 8 hr. The reaction mixture was concentrated to remove methyl alcohol, and water was added to the residue. The solution was extracted with n-hexane, and the n-hexane solution was dried over sodium sulfate. The dried n-hexane solution was concentrated and the residue was distilled to give 280 mg of oily product under reduced pressure.

Quelle