Reaktion #52362

ord-f22cfd7a18f345d98212699d5f724046

Reaktionsgleichung

O=C([O-])[O-].[K+].[K+]
potassium carbonate
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
Intermediate 28
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene
CO
methanol
→
C#Cc1ccc2c(c1)C(C)(C)CCC2N(C)C(C)C
title compound
Ausbeute 80.0%
C#Cc1ccc2c(c1)C(C)(C)CCC2N(C)C(C)C
6-Ethynyl-1-(iso-propyl-methyl-amino)-4,4-dimethyl-1,2,3,4-tetrahydro-naphthalene
Ausbeute 80.0%

Edukte

O=C([O-])[O-].[K+].[K+]
potassium carbonate
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
Intermediate 28
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene
CO
methanol

Reagenzien

Keine

Lösungsmittel

CCOC(C)=O
ethyl acetate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following general procedure E and using 1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene (Intermediate 28, 0.14 g, 0.45 mmol), methanol (5 mL), potassium carbonate (0.61 g, 4.41 mmol) and ethyl acetate the title compound (0.092 g, 80%) was obtained as an oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06855512B2uspto-grants-2005_02