Reaktion #52308

Reaktionsgleichung

Sodium thiomethoxide

3,5-dibromopyridine

→

title compound

Ausbeute 89.0%

3-Bromo-5-methylsulfanyl-pyridine

Ausbeute 89.0%

Lösungsmittel

ethyl acetate

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed several times with brine
2. 2
   TrocknenThe extracts were dried over magnesium sulfate
3. 3
   Sonstigethe solvent was removed under reduced pressure
4. 4
   SonstigeThe crude material was chromatographed on silica (10% ethyl acetate/hexanes)

Vorschrift

Sodium thiomethoxide (1.6 g, 23 mmol) was added to a solution of 3,5-dibromopyridine (5 g, 21 mmol) in DMF (25 mL). After stirring overnight at room temperature, the reaction mixture was diluted with ethyl acetate and washed several times with brine. The extracts were dried over magnesium sulfate and the solvent was removed under reduced pressure. The crude material was chromatographed on silica (10% ethyl acetate/hexanes) to give the title compound (3.8 g, 89% yield) as a clear oil.

Quelle