Reaktion #523000

Reaktionsgleichung

sodium hydroxide

1-carbomethoxy-3-(p-n-propoxyphenyl) thiourea

Potassium carbonate

→

methyl-6-n-propoxybenzothiazole-2-carbamate

Lösungsmittel

water

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONTo a stirred suspension of 2.2 g
2. 2
   workup.ADDITIONis then added to this reaction mixture
3. 3
   ExtraktionIt is then extracted by 2 × 50 ml chloroform
4. 4
   TrocknenThe chloroform extracts are dried over anhydrous Na2SO4
5. 5
   Sonstigethe solvent is removed by evaporation
6. 6
   Sonstigeto give 2 g

Vorschrift

To a stirred suspension of 2.2 g. 1-carbomethoxy-3-(p-n-propoxyphenyl) thiourea in a solution of 2.42 g. sodium hydroxide in 35 ml of water, in an erlenmeyer flask at 64° (by water bath) is added a solution of 8.8 g. potassium ferricyanide in 20 ml water. The stirring is continued for 2 additional hrs. Potassium carbonate, 6 g. is then added to this reaction mixture and stirring is continued for another 2 hr. period. It is then extracted by 2 × 50 ml chloroform. The chloroform extracts are dried over anhydrous Na2SO4 and the solvent is removed by evaporation to give 2 g. of the product. m.p. 178°-180° C.

Quelle