Reaktion #522794

Reaktionsgleichung

1-(2-chloro-10,11-dihydro-dibenzo[b,f]thiepin--10-yl)-piperazine

potassium carbonate

potassium iodide

N-(β-chloroethyl)--oxazolidinone

→

3-[2-[4-(2-chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-ethyl]-2-oxazolidinone

Lösungsmittel

toluene

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is heated
2. 2
   Temperaturunder reflux for 22 hours
3. 3
   Waschenthe organic phase washed with saturated soda solution and water
4. 4
   Trocknendried over sodium sulphate
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

7.8 g of 1-(2-chloro-10,11-dihydro-dibenzo[b,f]thiepin--10-yl)-piperazine are treated, together with 11.6 g of powdered potassium carbonate, 0.2 g of potassium iodide and 100 ml of toluene, with 8.22 g of N-(β-chloroethyl)--oxazolidinone and the mixture is heated under reflux for 22 hours. Then the mixture poured on to water and the organic phase washed with saturated soda solution and water, dried over sodium sulphate and concentrated under reduced pressure. There is obtained crude liquid 3-[2-[4-(2-chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-ethyl]-2-oxazolidinone. The maleate is prepared by treatment with maleic acid in ethanol/ether; melting point 173°-175° C.

Quelle