Reaktion #522784

Reaktionsgleichung

1-(10,11-dihydro-2-methyl-dibenzo[b,f]thiepin--10-yl)-piperazine

potassium carbonate

potassium iodide

β-chloroethyl-oxazolidinone

→

3-[2-[4-(10,11-dihydro--2-methyl-dibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-ethyl]--2-oxazolidinone

Lösungsmittel

toluene

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is heated for 24 hours
2. 2
   Temperaturunder reflux
3. 3
   Waschenthe organic phase washed with saturated soda solution and water
4. 4
   Trocknendried over sodium sulphate
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

2.7 g of 1-(10,11-dihydro-2-methyl-dibenzo[b,f]thiepin--10-yl)-piperazine are treated, together with 4.3 g of powdered potassium carbonate, 200 mg of potassium iodide and 90 ml of toluene, with 3.2 g of N-(β-chloroethyl-oxazolidinone and the mixture is heated for 24 hours under reflux. Then the mixture is poured on to ice-water, diluted with benzene and the organic phase washed with saturated soda solution and water, dried over sodium sulphate and concentrated under reduced pressure. There is obtained 3-[2-[4-(10,11-dihydro--2-methyl-dibenzo[b,f]thiepin-10-yl)-1-piperazinyl]-ethyl]--2-oxazolidinone which is recrystallised from acetone/petroleum ether. The maleate melts at 159°-161° C.

Quelle