Reaktion #5225

Reaktionsgleichung

2(1H)-Oxo-quinoline-3,4-dicarboxylic acid

phosphorous oxychloride

→

4-Chloro-furo[3,4-c]quinoline-1,3-dione

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed
2. 2
   EinengenThe reaction mixture was concentrated in vacuo
3. 3
   workup.ADDITIONthe residue treated with ice water

Vorschrift

A mixture of 2(1H)-Oxo-quinoline-3,4-dicarboxylic acid (2.0 g), phosphorous oxychloride (10 mL) and 8 drops of dimethyl formamide was refluxed with stirring for 20 min. The reaction mixture was concentrated in vacuo and the residue treated with ice water to afford 4-Chloro-furo[3,4-c]quinoline-1,3-dione as a tan solid.

Quelle