Reaktion #52225

Reaktionsgleichung

4-fluoro-3-methoxyaniline

glyoxal 1,1-dimethyl acetal

→

N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline

Ausbeute 101.1%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeRemoval of the catalyst
2. 2
   Filtrationby filtration and evaporation of solvent in vacuo

Vorschrift

To a solution of 4-fluoro-3-methoxyaniline (0.98 g 6.9 mmol) in ethanol (20 ml) was added glyoxal 1,1-dimethyl acetal (0.89 g 8.27 mmol). Pd/C 5% (50 mg) was added and the mixture hydrogenated. Removal of the catalyst by filtration and evaporation of solvent in vacuo gave N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline 1.6 g

Quelle