Reaktion #52223

Reaktionsgleichung

Methyl 1-acetyl-2,3-dihydroindol-3-one-6-carboxylate

trimethyl orthoformate

p-toluene sulphonic acid

→

Methyl 1-acetyl-3-methoxyindole-6-carboxylate

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated under reduced pressure
2. 2
   workup.ADDITIONpoured into water
3. 3
   Extraktionextracted with chloroform
4. 4
   SonstigeAfter drying
5. 5
   Sonstigeevaporation
6. 6
   Sonstigethe product was purified by prep hplc

Vorschrift

Methyl 1-acetyl-2,3-dihydroindol-3-one-6-carboxylate (233 mg, 1 mmol), trimethyl orthoformate (10 ml) and p-toluene sulphonic acid (20 mg) were heated under reflux for 3 h. in methanol (10 ml). The reaction mixture was concentrated under reduced pressure, poured into water and extracted with chloroform. After drying and evaporation, the product was purified by prep hplc;

Quelle