Reaktion #52205

Reaktionsgleichung

2-amino-6-chloro-3-nitropyridine

sodium thiophenolate

→

2-amino-3-nitro-6-(phenylmercapto)pyridine

Ausbeute 95.0%

Lösungsmittel

water

2-propanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige2-amino-3-nitro-6-(phenylmercapto)pyridine was prepared
2. 2
   Temperaturunder reflux for 2 hours
3. 3
   Filtrationthe solid was collected by vacuum filtration
4. 4
   Waschenwashed with water and 2-propanol
5. 5
   Sonstigedried at 50° C. under vacuum

Vorschrift

2-amino-3-nitro-6-(phenylmercapto)pyridine was prepared by heating 2-amino-6-chloro-3-nitropyridine (84.0 g, 0.484 mol) and sodium thiophenolate (Fluka) (72.0 g, 0.545 mol) in 2-propanol (1500 mL) under reflux for 2 hours. After cooling to room temperature the suspension was diluted with water (100 ml), the solid was collected by vacuum filtration, washed with water and 2-propanol, and dried at 50° C. under vacuum to give 109.1 g (95% yield) of 2-amino-3-nitro-6-(phenylmercapto)pyridine, m.p. 148-152° C.).

Quelle