Reaktion #52202

Reaktionsgleichung

2,4-Dichlorobenzenesulphonyl chloride

2-methoxyethylamine

→

title compound

2,4-Dichloro-1-(2-methoxyethylsulphamoyl)benzene

Lösungsmittel

n-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for one hour
2. 2
   SonstigeThe volatiles were removed by evaporation and residue
3. 3
   Sonstigepurified by chromatography
4. 4
   Wascheneluting with hexane/ethyl acetate (50:50)

Vorschrift

2,4-Dichlorobenzenesulphonyl chloride (500 mg 2.1 mmol) and 2-methoxyethylamine (230 mg, 3.1 mmol) in n-butanol (10 ml) was heated at reflux for one hour. The volatiles were removed by evaporation and residue purified by chromatography eluting with hexane/ethyl acetate (50:50) to give the title compound. NMR: 3.04 (q, 21), 3.08 (s, 3H), 3.22 (t, 2H), 7.60 (dd, 31), 7.82 (d, 1H), 7.92 (d, 1H), 8.0 (s, 2H); m/z: 282 [M−H]−.

Quelle