Reaktion #522005

Reaktionsgleichung

Ethanol

hydrogen chloride

2-(5-Chloro-2-methoxy-3-methylphenyl)-2-trimethylsiloxyethanenitrile

ethanol

→

ethyl 1-(5-chloro-2-methoxy-3-methylphenyl)-1-hydroxymethanecarboximidate hydrochloride

Ausbeute 89.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe temperature less than 10° C
2. 2
   Sonstigeevaporated to dryness
3. 3
   Sonstigethe residue triturated with ether

Vorschrift

Ethanol (100 ml.) was saturated with hydrogen chloride at 0° C. 2-(5-Chloro-2-methoxy-3-methylphenyl)-2-trimethylsiloxyethanenitrile (2.9 g.) in 5 ml. of ethanol was added dropwise, keeping the temperature less than 10° C. The reaction mixture was stirred at 0° C. for about 1 hour, evaporated to dryness and the residue triturated with ether to yield ethyl 1-(5-chloro-2-methoxy-3-methylphenyl)-1-hydroxymethanecarboximidate hydrochloride [2.67 g., 89%; m.p. 131°-133° C. (dec); ir (KBr) 1653; 1538, 1488, 1227, 1093 cm-1 ].

Quelle