Reaktion #521878

Reaktionsgleichung

3-hydroxypiperidine

8,9-Difluoro-2-methyl-1,2-dihydro-6-oxo-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid

3-hydroxypiperidine

→

8-fluoro-9-(3-hydroxy-1-piperidyl)-2-methyl-1,2-dihydro-6-oxo-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid

Ausbeute 38.3%

Lösungsmittel

hexamethylphosphoric triamide

hexamethylphosphoric triamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwith heating at 120° to 130° C. for 7 hours
2. 2
   workup.DISTILLATIONwere distilled off under reduced pressure
3. 3
   SonstigeRecrystallization of the residue from dimethylformamide

Vorschrift

8,9-Difluoro-2-methyl-1,2-dihydro-6-oxo-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid (5 g) and a solution of 7.5 g of 3-hydroxypiperidine in 50 ml of hexamethylphosphoric triamide were reacted with heating at 120° to 130° C. for 7 hours with stirring. After completion of reaction, hexamethylphosphoric triamide and unreacted 3-hydroxypiperidine were distilled off under reduced pressure. Recrystallization of the residue from dimethylformamide gave 2.5 g of 8-fluoro-9-(3-hydroxy-1-piperidyl)-2-methyl-1,2-dihydro-6-oxo-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid. m.p. 251°-253° C.

Quelle