Reaktion #521875

Reaktionsgleichung

9-chloro-8-fluoro-2-methyl-1,2-dihydro-6-oxo-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid

pyrrolidone

→

9-(1-pyrrolidinyl)-8-fluoro-2-methyl-1,2-dihydro-6-oxo-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid

Ausbeute 39.8%

Lösungsmittel

hexamethylphosphoric triamide

hexamethylphosphoric triamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas reacted at 150° C. for 8 hours
2. 2
   workup.DISTILLATIONwas distilled off under reduced pressure
3. 3
   Sonstigethe residue was recrystallized repeatedly from dimethylformamide

Vorschrift

A mixture of 56 g of 9-chloro-8-fluoro-2-methyl-1,2-dihydro-6-oxo-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid, 71 g of pyrrolidone and 60 ml of hexamethylphosphoric triamide in a stainless steel autoclave was reacted at 150° C. for 8 hours. After completion of reaction, hexamethylphosphoric triamide was distilled off under reduced pressure and the residue was recrystallized repeatedly from dimethylformamide to give 25 g of 9-(1-pyrrolidinyl)-8-fluoro-2-methyl-1,2-dihydro-6-oxo-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid. m.p. not lower than 300° C., pale yellow rhombic crystals.

Quelle