Reaktion #52176

Reaktionsgleichung

diethyl (S)-2-(4-nitrophthalimido)glutarate

→

diethyl (S)-2-(4-aminophthalimido)glutarate

Ausbeute 88.8%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solution was filtered through celite and
2. 2
   Einengenconcentrated in vacuo
3. 3
   SonstigeThe residue was purified by chromatography on silica gel (250 g)
4. 4
   Wascheneluting with diethyl ether:hexane (4:1)

Vorschrift

A suspension of diethyl (S)-2-(4-nitrophthalimido)glutarate (35.6 g, 94.1 mmol) and 10% palladium on carbon (0.5 g) (Aldrich) in ethanol (200 ml) was shaken under a hydrogen atmosphere (40-50 psi) for 26 hours. The solution was filtered through celite and concentrated in vacuo. The residue was purified by chromatography on silica gel (250 g) eluting with diethyl ether:hexane (4:1) to give diethyl (S)-2-(4-aminophthalimido)glutarate as a viscous yellow oil (29.1 g).

Quelle