Reaktion #520729

ord-3379c9897208485aa2ee63f7576f08dd

Reaktionsgleichung

C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
N-(3-chlorophenylacetyl)alanine
CN(C)CCO
2-(N,N-dimethyl amino) ethanol
→
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)OCCN(C)C
title compound
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)OCCN(C)C
N-[(3-Chlorophenyl)acetyl]alanine 2-(N,N-Dimethylamino)ethyl Ester

Edukte

C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
N-(3-chlorophenylacetyl)alanine
CN(C)CCO
2-(N,N-dimethyl amino) ethanol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following General Procedure BC above, and using N-(3-chlorophenylacetyl)alanine (from Example BD above) and 2-(N,N-dimethyl amino) ethanol (Aldrich), the title compound can be prepared. The reaction was monitored by tlc on silica gel and purification was by liquid chromatography using 0.1:2:0.79 NH4OH:EtOH:CHCl3 as the eluant.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06667305B1uspto-grants-2003_12