Reaktion #520578

ord-fbe36586deb84ed3b619d7822716589d

Reaktionsgleichung

C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O
N-(3,5-difluorophenylacetyl)-L-alanine
C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O
N-(3,5-Difluorophenylacetyl)-L-alanine
NC1CCc2ccccc2NC1=O
3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
→
C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)NC1CCc2ccccc2NC1=O
title compound
C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)NC1CCc2ccccc2NC1=O
3-(N′-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

Edukte

C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O
N-(3,5-difluorophenylacetyl)-L-alanine
C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O
N-(3,5-Difluorophenylacetyl)-L-alanine
NC1CCc2ccccc2NC1=O
3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe reaction was monitored by tlc on silica gel (Rf=0.15 in 12% methanol/dichloromethane) and purification

Vorschrift

Following General Procedure A above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (General Procedure 6-B), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.15 in 12% methanol/dichloromethane) and purification was by flash chromatography using 12% methanol/dichloromethane as the eluant.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06667305B1uspto-grants-2003_12