Reaktion #5205

ord-5a0095e69f164f00815bcbd1c99cbbde

Reaktionsgleichung

COc1ccc(CSC[C@@H]2CCCN2C)cc1
(2S)-2-(4-methoxybenzylthiomethyl)-1-methylpyrrolidine
COS(=O)(=O)F
methyl fluorosulfonate
→
COc1ccc(CSC[C@@H]2CCC[N+]2(C)C)cc1.O=S(=O)([O-])F
title compound
COc1ccc(CSC[C@@H]2CCC[N+]2(C)C)cc1.O=S(=O)([O-])F
(2S)-1,1-Dimethyl-2-(4-methoxybenzylthiomethyl)-pyrrolidinium fluorosulfonate

Edukte

COc1ccc(CSC[C@@H]2CCCN2C)cc1
(2S)-2-(4-methoxybenzylthiomethyl)-1-methylpyrrolidine
COS(=O)(=O)F
methyl fluorosulfonate

Reagenzien

Keine

Lösungsmittel

ClCCl
methylene chloride

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe procedure described in Preparation 5-(5)

Vorschrift

The procedure described in Preparation 5-(5) was repeated, but using 740 mg of (2S)-2-(4-methoxybenzylthiomethyl)-1-methylpyrrolidine and 243 μl of methyl fluorosulfonate in the presence of 22 ml of methylene chloride, to afford 1.0 g of the title compound as crystals, melting at 150°-153° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05242914uspto-grants-1993_09