Reaktion #52043

ord-36905fa681b1473c9ca583a21c17dc15

Reaktionsgleichung

O=[N+]([O-])c1cnc2ccccc2c1Cl
4-chloro-3-nitro-quinoline
CC(C)CN
isobutyl amine
CCN(CC)CC
triethylamine
→
CC(C)Cc1c([N+](=O)[O-])cnc2ccccc12
4-isobutyl-3-nitro quinoline

Edukte

O=[N+]([O-])c1cnc2ccccc2c1Cl
4-chloro-3-nitro-quinoline
CC(C)CN
isobutyl amine
CCN(CC)CC
triethylamine

Reagenzien

Keine

Lösungsmittel

Cc1ccccc1
toluene

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    WaschenAfter washing
  2. 2
    Sonstigephase separation

Vorschrift

4-chloro-3-nitro-quinoline is reacted with isobutyl amine in the presence of triethylamine (TEA) at between −10 and +15° C. in toluene, while excluding moisture. After washing and phase separation, the organic solution is ready for the next step.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06852861B2uspto-grants-2005_02