Reaktion #51970

Reaktionsgleichung

4-acetamidoacetophenone

bromine

→

title compound

Ausbeute 62.5%

N-[4-(2-bromoacetyl)phenyl]acetamide

Ausbeute 62.5%

Lösungsmittel

1,4-dioxane diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solid was collected by filtration
2. 2
   Waschenwashed with diethyl ether
3. 3
   Sonstigedried under high vacuum

Vorschrift

To a suspension of 4-acetamidoacetophenone (Lancaster, 5.32 g, 0.03 mol) in 1,4-dioxane/diethyl ether (100 mL, 1:2, v/v) was added bromine (1.53 mL, 0.03 mol) via a syringe. The reaction mixture was stirred at room temperature for 4 hours until the color of the mixture was changed from brown to white. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum to give the title compound as a white solid (4.8 g).

Quelle