Reaktion #51891

Reaktionsgleichung

3-trifluoromethyl-4-[bis(2-hydroxyethyl) amino]benzonitrile

NaOH

ethanol

→

white crystals

3-trifluoromethyl-4-[bis(2-hydroxyethyl) amino]benzoic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solution was partitioned between EtOAc (120 ml) and HCl (50 ml, 0.4 M)
2. 2
   Waschenthe aqueous layer washed with EtOAc (3×25 ml)
3. 3
   Trocknenthe combined organic layers dried (MgSO4)
4. 4
   Sonstigeevaporated to dryness
5. 5
   SonstigeThe residue was recrystallized from EtOAc

Vorschrift

A solution of the 3-trifluoromethyl-4-[bis(2-hydroxyethyl) amino]benzonitrile and NaOH (0.8 g, 0.02 mol) in aqueous ethanol (10 ml, 50%) was refluxed for 2 hours. The solution was partitioned between EtOAc (120 ml) and HCl (50 ml, 0.4 M), the aqueous layer washed with EtOAc (3×25 ml), the combined organic layers dried (MgSO4) and evaporated to dryness. The residue was recrystallized from EtOAc to give 0.39 g of white crystals.

Quelle