Reaktion #51871

Reaktionsgleichung

hydroxylamine

2-ureidoacetate

→

N-hydroxy-2-ureidoacetamide

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter 24 h the resin was filtered
2. 2
   Waschenwashed with acetonitrile
3. 3
   Sonstigepurified by preparative reverse-phase (C18) HPLC

Vorschrift

The ArgoGel-Wang or ArgoGel-OH resin bound 2-ureidoacetate 6 (0.25 g) was treated with dioxane (1 mL) and aqueous 50% hydroxylamine (2 mL). After 24 h the resin was filtered, washed with acetonitrile and the filtrates combined and purified by preparative reverse-phase (C18) HPLC to yield product N-hydroxy-2-ureidoacetamide (I).

Quelle