Reaktion #518082

Reaktionsgleichung

NaOH

1,3-bis[2-(2-methoxyethoxy)ethoxy]-2-propanol

2-chloroethylmethylether

→

1,3-bis[2-(2-methoxyethoxy)ethoxy]-2-(2-methoxyethoxy)propane

Ausbeute 85.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the completion of dropwise addition
2. 2
   workup.STIRRINGthe mixture was stirred for about 2 hours
3. 3
   Filtrationa precipitated salt was filtered off
4. 4
   Sonstigecondensed
5. 5
   workup.DISTILLATIONpurified by a vacuum distillation

Vorschrift

20.4 g (0.51 mol) of NaOH pellets were added to 100 g (0.34 mol) of 1,3-bis[2-(2-methoxyethoxy)ethoxy]-2-propanol resulting from Step 1. 48.2 g (0.51 mol) of 2-chloroethylmethylether was dropwise added in small portions while stirring at 60° C. After the completion of dropwise addition, the mixture was stirred for about 2 hours and a precipitated salt was filtered off, the filtrate was condensed and purified by a vacuum distillation to give 102 g of 1,3-bis[2-(2-methoxyethoxy)ethoxy]-2-(2-methoxyethoxy)propane (E) (yield: 85%). The distillation temperature was from 155 to 161° C./0.2 mmHg.

Quelle