Reaktion #517758

Reaktionsgleichung

ethyl 4-hydroxy-7-methoxyquinoline-3-carboxylate

hydrochloric acid

→

4-hydroxy-7-methoxyquinoline-3-carboxylic acid

Ausbeute 98.8%

Lösungsmittel

sodium hydroxide water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux for 1.5 hr
3. 3
   SonstigeThe resulting precipitate was isolated by filtration
4. 4
   Waschenwashed twice with water
5. 5
   Sonstigedried overnight in a vacuum oven at 80° C.

Vorschrift

A suspension of ethyl 4-hydroxy-7-methoxyquinoline-3-carboxylate (12.0 g, 48 mmol) in 10% sodium hydroxide/water (200 mL) was heated at reflux for 1.5 hr. The reaction mixture was allowed to cool to ambient temperature and then made acidic (pH=3) by the dropwise addition of concentrated hydrochloric acid. The resulting precipitate was isolated by filtration, washed twice with water and then dried overnight in a vacuum oven at 80° C. to provide 10.4 g of 4-hydroxy-7-methoxyquinoline-3-carboxylic acid.

Quelle