Reaktion #51772

Reaktionsgleichung

4-tert-butyl-1-methyl-2-nitrobenzene

potassium

Et2O

diethyl oxalate

→

title compound

3-(4-tert-Butyl-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester

Lösungsmittel

EtOH

Reaktionsbedingungen

Vorschrift

The title compound was prepared by adapting the procedure described by Gagliardi S., et al., in J. Med. Chem., 1998;41:1568 using potassium (1.66 g, 42.4 mmol), Et2O (200 mL), EtOH (10 mL), diethyl oxalate (7.56 g, 51.8 mmol), and 4-tert-butyl-1-methyl-2-nitrobenzene (prepared in Example WW; 10.0 g, 51.8 mmol). MS(APCI): 294 (M+H).

Quelle