Reaktion #517613

Reaktionsgleichung

ethyl 2-(N-ethyl-N-methylsulphonylamino)-4-methylsulphonylbenzoate

lithium hydroxide monohydrate

hydrochloric acid

→

2-(N-ethyl-N-methylsulphonylamino)-4-methylsulphonylbenzoic acid

Ausbeute 90.4%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   TrocknenThe combined organic extracts were dried (magnesium sulphate)
3. 3
   Filtrationfiltered
4. 4
   Sonstigeevaporated

Vorschrift

A mixture of ethyl 2-(N-ethyl-N-methylsulphonylamino)-4-methylsulphonylbenzoate (11.4 g) and lithium hydroxide monohydrate (1.37 g) in aqueous ethanol (50%) was stirred at room temperature for 19 hours. The mixture was then acidified with conc. hydrochloric acid and extracted with ethyl acetate. The combined organic extracts were dried (magnesium sulphate), filtered and evaporated to yield 2-(N-ethyl-N-methylsulphonylamino)-4-methylsulphonylbenzoic acid as a brown solid (9.48 g), NMR (acetone-d6); 1.15(t,3H), 2.98(s,3H), 3.22(s.3H), 3.85(q,2H), 8.0-8.25(m,3H).

Quelle