Reaktion #51734

ord-40032671f70349e69914f1df3250ff7f

Reaktionsgleichung

CCOC(=O)[C@@H](O)C(=O)CC(CCc1ccsc1)C(C)C
(S)-hydroxy-6-methyl-3-oxo-5-(2-thiophen-3-yl-ethyl)-heptanoic acid ethyl ester
[Na+].[OH-]
NaOH
→
CC(C)[C@]1(CCc2ccsc2)CC(O)=CC(=O)O1
title compound
CC(C)[C@]1(CCc2ccsc2)CC(O)=CC(=O)O1
(S)-4-Hydroxy-6-isopropyl-6-(2-thiophen-3-yl-ethyl)-5,6-dihydro-pyran-2-one

Edukte

CCOC(=O)[C@@H](O)C(=O)CC(CCc1ccsc1)C(C)C
(S)-hydroxy-6-methyl-3-oxo-5-(2-thiophen-3-yl-ethyl)-heptanoic acid ethyl ester
[Na+].[OH-]
NaOH

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product was triturated from Et2O, mp 117-123° C.

Vorschrift

The title compound was prepared as described in General Method 8 using (S)-hydroxy-6-methyl-3-oxo-5-(2-thiophen-3-yl-ethyl)-heptanoic acid ethyl ester (6.4 mmol), 0.1N NaOH (400 mL), and THF (40 mL). The product was triturated from Et2O, mp 117-123° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06852711B2uspto-grants-2005_02