Reaktion #51723

Reaktionsgleichung

4-methyl-1-(4-methyl-thiazol-5-yl)-pent-1-en-3-one

MeOH

→

title compound

4-Methyl-1-(4-methyl-thiazol-5-yl)-pentan-3-one

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was prepared
2. 2
   SonstigeThe crude product was chromatographed on silica gel
3. 3
   Wascheneluting with 2:1 hexane

Vorschrift

The title compound was prepared as described in General Method 3 using 1.73 g (8.86 mmol) of 4-methyl-1-(4-methyl-thiazol-5-yl)-pent-1-en-3-one (prepared in Example B-1) and 0.4 g of 5% Pd/BaSO4 in THF:MeOH (25 mL:25 mL). The crude product was chromatographed on silica gel, eluting with 2:1 hexane:EtOAc, to give the title compound. 1H NMR (CDCl3): δ 1.03 (d, 6H), 2.35 (s, 3H), 2.49-2.56 (m, 1H), 2.72 (t, 2H), 2.98 (t, 2H), 8.49 (s, 1H).

Quelle