Reaktion #517226

Reaktionsgleichung

Diphenylphosphine

methyl 2-trifluoromethanesulfonyloxy-1-naphthoate

triethylamine

1,4-bis(diphenylphosphino)butane

→

Methyl 2-diphenylphosphino-1-naphthoate

Lösungsmittel

MeCN

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeinstantly giving a red coloration
2. 2
   TemperaturThe solution was heated
3. 3
   Temperaturat reflux under nitrogen for 17 hours
4. 4
   Temperaturto cool

Vorschrift

Diphenylphosphine (0.55 mL, 3.16 mmol, 1 eq) was added to a stirred solution of methyl 2-trifluoromethanesulfonyloxy-1-naphthoate (1.047 g, 3.13 mmol, 1 eq), triethylamine (0. 5 mL, 3.59 mmol, 1.1 eq), 1,4-bis(diphenylphosphino)butane (dppb) (0.03 g, 0.07 mmol, 0.02 eq) and palladium acetate (0.005 g, 0.02 mmol, 0.006 eq) in degassed MeCN (10 mL) instantly giving a red coloration. The solution was heated at reflux under nitrogen for 17 hours. The blood-red solution was allowed to cool and an aliquot taken for NMR analysis.

Quelle