Reaktion #51650

Reaktionsgleichung

NH4Cl

ICH2Cl

(3R)-methyl 1-[(S)-1-phenylethyl]pyrrolidine-3-acetate

lithium diisopropylamide

→

(5R)-3-oxo-1-[(1S)-1-phenylethyl]-1-azoniabicyclo[3.2.1]octane chloride

Ausbeute 36.6%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigea maximum of −40° C.
2. 2
   workup.ADDITIONduring this addition
3. 3
   workup.WAITAfter 1 h
4. 4
   SonstigeThe organic layer was separated
5. 5
   Trocknendried (MgSO4)
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated
8. 8
   SonstigeThe resulting red-brown foam was chromatographed (300 g SiO2, CHCl3—MeOH—NH4OH (89:10:1)
9. 9
   Einengenconcentrated

Vorschrift

A solution of (3R)-methyl 1-[(S)-1-phenylethyl]pyrrolidine-3-acetate (25.72 g, 104.0 mmol) in THF (265 mL) was cooled under N2 in a CO2/acetone bath. Next, ICH2Cl (22.7 mL, 312.0 mmol) was added, and the mixture stirred for 30 min. A solution of 2.0M lithium diisopropylamide (heptane/THF/ethylbenzene, 156 mL, 312 mmol) was added slowly over 30 min. The internal temperature reached a maximum of −40° C. during this addition. After 1 h, sat. NH4Cl (100 mL) was added and the mixture was allowed to warm to rt. The organic layer was separated, dried (MgSO4), filtered and concentrated. The resulting red-brown foam was chromatographed (300 g SiO2, CHCl3—MeOH—NH4OH (89:10:1) followed by CHCl3—MeOH (3:1). The product fractions were pooled and concentrated to afford (5R)-3-oxo-1-[(1S)-1-phenylethyl]-1-azoniabicyclo[3.2.1]octane chloride (10.12 g) as a tan foam (MS (ESI+) m/z 230.1 (M+H+). This foam (10.1 g, 38 mmol) was taken up in MeOH (500 mL), 10% Pd(C) (3.0 g) added and the mixture was hydrogenated (45 psi) overnight. The mixture was filtered and re-subjected to the reduction conditions (9.1 g, 10% Pd/C, 50 psi). After 5 h, TLC indicated the consumption of the (5R)-3-oxo-1-[(1S)-1-phenylethyl]-1-azoniabicyclo[3.2.1]octane chloride. The mixture was filtered, concentrated and triturated (minimal iPrOH) to give 3.73 g of (5R)-1-azabicyclo[3.2.1]octan-3-one hydrochloride, in two crops, as an off-white solid: [α]25D=33 (c 0.97, DMSO). MS (EI) m/z 125 (M+). (3R,5R)-1-azabicyclo[3.2.1]octan-3-amine dihydrochloride

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