Reaktion #516416

Reaktionsgleichung

4′-Hydroxy[1,1′-biphenyl]-4-carboxylic acid

sulfuric acid

methanol

→

title compound

Ausbeute 95.0%

methyl 4′-hydroxy[1,1′-biphenyl]-4-carboxylate

Ausbeute 95.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux temperature for 24 hours
2. 2
   Filtrationfiltered
3. 3
   WaschenThe filter cake was washed with cold methanol (2×25 mL)
4. 4
   Sonstigedried under reduced pressure

Vorschrift

4′-Hydroxy[1,1′-biphenyl]-4-carboxylic acid (5.0 g, 23.34 mmol, purchased from Aldrich Chemical Co.) and sulfuric acid (0.5 mL) in methanol (100 mL) were heated at reflux temperature for 24 hours. The mixture was allowed to cool to ambient temperature and then filtered. The filter cake was washed with cold methanol (2×25 mL) and dried under reduced pressure to provide the title compound (95% yield).

Quelle