Reaktion #51634

Reaktionsgleichung

bromo(4-nitrophenyl)acetaldehyde

potassium thiocyanate

cyclohexylamine

→

desired compound

N-cyclohexyl-5-(4-nitrophenyl)-1,3-thiazol-2-amine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is heated
2. 2
   Temperaturunder reflux until completion of the reaction (5-12 hours)
3. 3
   Filtrationis filtered off
4. 4
   Waschenwashed with water
5. 5
   SonstigeThe crude material is purified by usual silica gel chromatography

Vorschrift

A solution of bromo(4-nitrophenyl)acetaldehyde and potassium thiocyanate (1.2 equivalents) in methanol is stirred at room temperature for 1 hour. The cyclohexylamine (1,05 equivalents) is added drop-wise and the mixture is heated under reflux until completion of the reaction (5-12 hours). After cooling to 0° C. the precipitate is filtered off and washed with water. The crude material is purified by usual silica gel chromatography to give the desired compound.

Quelle