Reaktion #516184

ord-70b09ec84c68476a83fb26cca84cff9f

Reaktionsgleichung

CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@H]3[C@H]1C5.Cl
hydromorphone HCl
→
CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@H]3[C@H]1C5
Hydromorphone

Edukte

—
polyethylene glycol
CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@H]3[C@H]1C5.Cl
hydromorphone HCl
—
hydroxypropyl methylcellulose
—
D&C Red No. 30 Aluminum Lake
—
hydroxypropyl cellulose

Reagenzien

[O-2].[O-2].[Ti+4]
titanium dioxide

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONadding Opadry® Y-5-1442
  2. 2
    workup.ADDITIONmixing for about 1 hour
  3. 3
    SonstigeThe resultant preparation

Vorschrift

Hydromorphone beads were prepared by dissolving hydromorphone HCl in water, adding Opadry® Y-5-1442, light pink (a product commercially available from Coloron, West Point, Pa., which contains hydroxypropyl methylcellulose, hydroxypropyl cellulose, titanium dioxide, polyethylene glycol and D&C Red No. 30 Aluminum Lake), 20% w/w, and mixing for about 1 hour, and then spraying onto nu pariel 18/20 beads using a Wurster insert. The resultant coated beads were then overcoated with Opadry® Y-5-1442 light pink (15% w/w). The resultant preparation had the formula set forth in Table 1 below:

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06316031B1uspto-grants-2001_11