Reaktion #51616

Reaktionsgleichung

2-chloro-6,7-dimethoxyquinoxaline

cyclohexylamine

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product

Ausbeute 69.0%

2-cyclohexylamino-6,7-dimethoxyquinoxaline

Ausbeute 69.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mix is partitioned between CH2Cl2 and saturated NaHCO3
2. 2
   TrocknenThe organic layer is dried (MgSO4)
3. 3
   Einengenconcentrated
4. 4
   SonstigeThe resulting syrup is chromatographed (1:1 EtOAc:CH2Cl2)

Vorschrift

To 0.3 g (1.34 mmol) of 2-chloro-6,7-dimethoxyquinoxaline is added approx. 1 mL of cyclohexylamine. The mixture is heated overnight at 105° C. and a further 10 hours at 135° C. The mix is partitioned between CH2Cl2 and saturated NaHCO3. The organic layer is dried (MgSO4) and concentrated. The resulting syrup is chromatographed (1:1 EtOAc:CH2Cl2) to provide 0.265 g of the product as a lt. brown solid in 69% yield (m.p. 188-189.5). Anal. calcd for C16H21N3O2: C, 66.88; H, 7.37; N, 14.62. Found: C, 66.82; H, 7.28; N, 14.45.

Quelle