Reaktion #51610

Reaktionsgleichung

1-(phenylmethyl)-4-piperidinemethanamine

acrylonitrile

→

3-[[[1-(phenylmethyl)-4-piperidinyl]methyl]-amino]-propanenitrile

Ausbeute 102.4%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 4 hours
2. 2
   SonstigeThe solvent was evaporated

Vorschrift

A mixture of 1-(phenylmethyl)-4-piperidinemethanamine (0.076 mol) and acrylonitrile (0.076 mol) in ethanol (250 ml) was stirred and refluxed for 4 hours. The solvent was evaporated, yielding 20.0 g (102.4%, crude residue, used in next reaction step, without further purification) of 3-[[[1-(phenylmethyl)-4-piperidinyl]methyl]-amino]-propanenitrile (interm. 14).

Quelle