Reaktion #51605

Reaktionsgleichung

5F

(3-Benzyloxy-5-trifluoromethylthien-2-yl)-carboxylic acid

→

liquid

Ausbeute 71.0%

3-Benzyloxy-5-trifluoromethylthiophen

Ausbeute 71.0%

Lösungsmittel

quinoline

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is heated for 25 minutes at 150° C.
2. 2
   Temperaturcooled to room temperature
3. 3
   FiltrationThe mixture was filtered
4. 4
   Waschenwashed with water
5. 5
   Extraktionextracted with diethyl ether twice
6. 6
   WaschenThe combined organic phases were washed with water
7. 7
   Sonstigedried
8. 8
   EinengenThe mixture was concentrated
9. 9
   Sonstigethe residue was chromatographed

Vorschrift

A mixture of 5F (14.5 g) and quinoline (50 ml) was treated with copper powder (4.57 g) and heated to 150° C. The reaction mixture is heated for 25 minutes at 150° C. and cooled to room temperature. The mixture was filtered and washed with water. Aqueous quinoline was acidified with 6N HCl (pH=2) and extracted with diethyl ether twice. The combined organic phases were washed with water and dried. The mixture was concentrated and the residue was chromatographed to yield a yellow liquid (8.74 g, 71%).

Quelle