Reaktion #515991

Reaktionsgleichung

1-(4-hydroxyphenyl)-propan-2-one

chloromethyl-dimethyl-(4-fluorophenyl)-silane

potassium carbonate

potassium iodide

→

title product

1-(4-[{Dimethyl-(4-fluorophenyl)-silyl}methoxy]phenyl)-propan-2-one

Lösungsmittel

dimethyl sulfoxide

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONare added
2. 2
   Extraktionthe ether phase is extracted
3. 3
   Waschenby washing several times with water and saturated sodium chloride solution
4. 4
   Trocknendried over sodium sulfate
5. 5
   Sonstigethe solvent is evaporated off
6. 6
   workup.DISTILLATIONDistillation at 150° C. (0.01 mbar)

Vorschrift

30 g of 1-(4-hydroxyphenyl)-propan-2-one and 45.5 g of chloromethyl-dimethyl-(4-fluorophenyl)-silane in 400 ml of dimethyl sulfoxide are stirred with 42 g of potassium carbonate and 2 g of potassium iodide for 12 hours at 70° C. The reaction mixture is poured into 1.6 liters of ice water and 500 ml of diethyl ether are added; the ether phase is extracted by washing several times with water and saturated sodium chloride solution and dried over sodium sulfate; the solvent is evaporated off. Distillation at 150° C. (0.01 mbar) yields the title product.

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