Reaktion #51562

Reaktionsgleichung

2-(2-bromo-5-chlorophenyl)-2-methyl-1,3-dioxolane

tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indole-9(8H)-carboxylate

→

title compound

1-{2-[(7bR,11aS)1,2,7b,8,9,10,11,11a-octahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indol-6-ylamino]-5-chlorophenyl}ethanone

Reaktionsbedingungen

Vorschrift

Using 2-(2-bromo-5-chlorophenyl)-2-methyl-1,3-dioxolane and following the procedures described in EXAMPLE 116, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indole-9(8H)-carboxylate from EXAMPLE 33, Part B was converted into the title compound of EXAMPLE 150. 1H NMR (CDCl3) δ: 10.26 (s, 1H), 7.72 (d, 1H, J=2.2 Hz), 7.20 (dd, 1H, J=9.2, 2.6 Hz), 6.96 (d, 1H, J=9.2 Hz), 6.84 (d, 1H, J=1.8 Hz), 6.77 (d, 1H, J=1.9 Hz), 6.87 (s, 1H), 3.74 (ABq, 2H, JAB=15.6 Hz), 3.63-3.57 (m, 1H), 3.50-3.42 (m, 1H), 3.40-3.30 (m, 1H), 3.20-3.02 (m, 5H), 2.98-2.90 (m, 1H), 2.66-2.58 (m, 1H), 2.61 (s, 3H), 2.05-1.97 (m, 2H). LRMS (ES)+: 391.4 (M+H)+. LRMS (ES)+: 414.4 (M+H)+.

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