Reaktion #515279

ord-1b2d0df55f0747d48bf9f86df2d4b8d1

Reaktionsgleichung

C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
3-chlorophenylacetyl alanine
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
N-(3-chlorophenylacetyl)alanine
OCc1cccs1
2-thiophenemethanol
→
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)OCc1cccs1
title compound
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)OCc1cccs1
N-[(3-chlorophenyl)acetyl]alanine 2-thienylmethyl Ester

Edukte

C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
3-chlorophenylacetyl alanine
C[C@H](NC(=O)Cc1cccc(Cl)c1)C(=O)O
N-(3-chlorophenylacetyl)alanine
OCc1cccs1
2-thiophenemethanol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following General Procedure C above, and using N-(3-chlorophenylacetyl alanine (from Example D above) and 2-thiophenemethanol (Aldrich) the title compound can be prepared. The reaction was monitored by tlc on silica gel and purification was by liquid chromatography using 3:7 EtOAc:hexane as the eluant.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06313152B1uspto-grants-2001_11