Reaktion #51477

Reaktionsgleichung

homopiperonylamine hydrochloride

triethylamine

chloroacetyl chloride

→

2-chloro-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide

Ausbeute 74.5%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction was partitioned with 1 N HCl
2. 2
   SonstigeThe organic layer was separated
3. 3
   Waschenwashed with aqueous bicarbonate
4. 4
   Trocknendried (Na2SO4)
5. 5
   Sonstigethe solvent was removed in vacuo

Vorschrift

To homopiperonylamine hydrochloride (2.14 g, 10.6 mmol) (a compound of formula (Y7)) in CH2Cl2 (20 mL) in an ice bath was added triethylamine (3.1 mL, 21 mmol) and chloroacetyl chloride (0.85 mL, 10 mmol) (a compound of formula (Y6)). After warming to ambient temperature and stirring for 16 hours, the reaction was partitioned with 1 N HCl. The organic layer was separated, washed with aqueous bicarbonate, dried (Na2SO4), and the solvent was removed in vacuo to give 1.8 g of 2-chloro-N-[2-(1,3-benzodioxol-5-yl)ethyl]acetamide, a compound of formula (Y8).

Quelle