Reaktion #514645

Reaktionsgleichung

1-(4-Methoxycarbonylphenylmethyl)-4-(4-pyridyl)piperazine

sodium hydroxide

→

1-(4-carboxyphenylmethyl)-4-(4-pyridyl)piperazine

Ausbeute 90.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated by evaporation to an aqueous solution of the sodium salt of the acid
2. 2
   Sonstigeto give a white precipitate which
3. 3
   Filtrationwas collected by filtration
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried

Vorschrift

1-(4-Methoxycarbonylphenylmethyl)-4-(4-pyridyl)piperazine (4.5 g) was dissolved in methanol (50 ml) and treated at ambient temperature with 2M aqueous sodium hydroxide (36 ml). The resulting solution was stirred at room temperature for 3 hours and concentrated by evaporation to an aqueous solution of the sodium salt of the acid. This solution was just acidified with glacial acetic acid (4.3 ml) to give a white precipitate which was collected by filtration, washed with water and dried to give 1-(4-carboxyphenylmethyl)-4-(4-pyridyl)piperazine in 90% yield.

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